What does it mean to lose our souls? How do we get it back when it’s gone? The soul is the core of a person. It’s the soul which yearns for more of God. When we’ve been disconnected from God it’s our soul that misses him. It can ache if it goes too long without him.
This tends to happen when our desires have been left unchecked. Desires, as opposed to needs - like food, shelter, warmth etc - will always have the potential to consume us because they can never be satisfied. And the more we desire, the more our desires are unmet. The more unmet desires we have the more we grow agitated, competitive and aggressive.
The Psalmist encourages us back from the chaos of unmet desires, to putting our hope in God once more. He is not something to be desired, but he is who we need. He alone satisfies all our longing. This is a call to come back to him once more.